Sharma Lab

Postdoc Wanted (Sharma Lab, University of Oklahoma)

The Sharma lab is currently seeking a highly motivated postdoctoral fellow having experience in Synthetic Organic Chemistry. A Ph.D. in Organic Synthesis is desirable and experience in multi-steps synthesis/organometallic chemistry is preferred. Our lab engages in the synthesis, assessment, and modification of potential therapeutic leads derived from natural products for the treatment of cancer, bacterial infections, and neurological disorders.  We use two complementary approaches isolation/semi-synthesis and method development/total-synthesis to access a library of diverse analogues to study structure-activity relationships (SAR). To advance our synthetic compounds, we are having a multidisciplinary collaboration with leading laboratories at the Vanderbilt University, Bridge Institute (University of Southern California), and Mount Sinai, New York with combined expertise in natural product isolation, organic synthesis, medicinal chemistry, computational chemistry and molecular pharmacology. Our current research includes novel bond forming reactions utilizing diazo synthons, biomimetic approaches, asymmetric catalysis and complex natural product total synthesis along with structural diversification to establish the SAR.

For recent publications, please see Chem. Commun. 2017, 53, 12205–12208, J. Org. Chem. 2018, 83, 2744–2752, Org. Lett. 2016, 18, 6340–6343 and Proc. Natl. Acad. Sci. 2016, 113, 6041–6046. We are currently funded by grants from ACS petroleum Research Funds, Oklahoma Center for the Advancement of Science and Technology, National Science Foundations and the National Institute of Health. If interested, contact Dr. Indrajeet Sharma, isharma@ou.edu with a CV, cover letter, and contact address of 3 references. In your cover letter, please summarize your research accomplishments, what interests you in our work, and future career goals. For more information, please visit our page: http://www.ou.edu/cas/chemistry/directory/faculty/indrajeet-sharma